Software for Digital Histology

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Our business

HS Analysis provides tissue analysis software for digital pathology and microscopy images.
Get best practice analysis solutions derived with state of the art artificial neural networks / Deep Learning to automate quantification of your images.

technology

Technology

The most up-to-date artificial intelligence is one key technology of automatic interpretation of tissue samples in the software of HS Analysis. Technically speaking, virtual slides are analyzed with deep learning. Virtual slides are digital images, that are produced by microscope roboters called slide scanner. In this way you quickly get quantitative results about effects of drug candidates on tissue.

Specialists of HS Analysis use the appropriate technology depending on requirements of customers.
Two examples of most used technologies are listed below.

Digital pathology is a promising method for quantitative automatization in pharmaceutical research. The key technology was the introduction of Whole-Slide Imaging (WSI) with digital slide scanners. They allow virtualization of the whole slide with large tissue sections in high microscopic resolution. Combination of WSI with automatic detection and quantification software enables numerous new possibilities and methods to search for drugs against diseases. HS Analysis develops automatic WSI quantification solutions for efficient workflows in pharmaceutical research. Our solutions are compatible with all slide scanner file formats.
Recent evolution in artificial neural networks allows reliable recognition of structures with complex morphology traits, similar like the human brain does. HS Analysis specialized in neural network applications and Deep Learning to detect your Region of Interest in automatic manner. Avoid manual annotations for ROI definition to achieve high throughput with short analysis times.
scope

Scope

Our quality standards apply also in terms of service, technical expertise and advice.
Our dedicated employees are happy to assist you with know-how and experience in your daily business.

  • 3D reconstruction & analysis of serial slides.

    Anatomy

    3D reconstruction & analysis of serial slides.
  • Detection of frequency and distribution of IHC labeled blood vessels (e.g. as indicator of tumor malignancy).

    Angiology

    Detection of frequency and distribution of IHC labeled blood vessels (e.g. as indicator of tumor malignancy).
  • Analysis of gut wall and gut villi & crypt.

    Gastroenterology

    Analysis of gut wall and gut villi & crypt.
  • Glomeruli detection & analysis of interstitial fibrosis in Kidney.

    Nephrology

    Glomeruli detection & analysis of interstitial fibrosis in Kidney.
  • Quantification of labeled parameters in skin.

    Dermatology

    Quantification of labeled parameters in skin.
  • 3D Analysis of Brain structures and Plaque Analysis in Alzheimer´s disease.

    Neuroscience

    3D Analysis of Brain structures and Plaque Analysis in Alzheimer´s disease.
  • Quantification of proliferation markers like Ki-67, p53, p21, Stathmin, H-Scoring etc.

    Oncology

    Quantification of proliferation markers like Ki-67, p53, p21, Stathmin, H-Scoring etc.
  • Alveoli analysis in lung tissue.

    Pneumology

    Alveoli analysis in lung tissue.
  • Osteon quantification, Osteocytes, Volkman’s Canal, Haversian Canal

    Osteology

    Osteon quantification, Osteocytes, Volkman’s Canal, Haversian Canal
  • 3D reconstruction & analysis of serial slides.

    Anatomy

    3D reconstruction & analysis of serial slides.
  • Detection of frequency and distribution of IHC labeled blood vessels (e.g. as indicator of tumor malignancy).

    Angiology

    Detection of frequency and distribution of IHC labeled blood vessels (e.g. as indicator of tumor malignancy).
  • Analysis of gut wall and gut villi & crypt.

    Gastroenterology

    Analysis of gut wall and gut villi & crypt.
  • Glomeruli detection & analysis of interstitial fibrosis in Kidney.

    Nephrology

    Glomeruli detection & analysis of interstitial fibrosis in Kidney.
  • Quantification of labeled parameters in skin.

    Dermatology

    Quantification of labeled parameters in skin.
  • 3D Analysis of Brain structures and Plaque Analysis in Alzheimer´s disease.

    Neuroscience

    3D Analysis of Brain structures and Plaque Analysis in Alzheimer´s disease.
  • Quantification of proliferation markers like Ki-67, p53, p21, Stathmin, H-Scoring etc.

    Oncology

    Quantification of proliferation markers like Ki-67, p53, p21, Stathmin, H-Scoring etc.
  • Alveoli analysis in lung tissue.

    Pneumology

    Alveoli analysis in lung tissue.
  • Osteon quantification, Osteocytes, Volkman’s Canal, Haversian Canal

    Osteology

    Osteon quantification, Osteocytes, Volkman’s Canal, Haversian Canal
projects-two

Projects

Research experts in pharmacology, bioscience and in university medical centers are permanently expected to increase efficiency and reduce timeinvest and cost.

HS Analysis delivers software solutions for precise image analysis. In that way the researcher is going to be supported to get qualitative and reproducible data.

The system reduces human errors, which are possible in manual evaluation. It finally allows to get Big Data results in a short time and at the end to analyse, manage and present them. That allows researchers to fulfill continuously increasing expectations concerning efficiency and output of results.

details

Glomeruli Detection

Detection of glomeruli by using a tensorflow model for brightfield data.
 

Cell Counting

Segmentation and counting of cells.
 

Internalization

Analysis of insulin receptors inside and outside of cytoplasm and the change over time.
You can run this workflow at the digital microscopy platform APEER.

Scratch Assay

Analysis of samples with scratches and the change of cell area over time.
 
You can run this workflow at the digital microscopy platform APEER.

Real time detection on microscopy devices

You look through the microscope and see in real time markings of the objects relevant to you. Subsequently, an automatic quantification of the detected objects takes place.

Blood vessel analysis

Blood vessels can be marked with immunohistochemistry.
This allows blood vessel counting and analysis of blood vessel distribution.
 

 

Annotation Software to set region of interests (ROI)

Manual drawing of regions of interest (ROI) as well as automatic ROI detection. Image analysis can be restricted to ROIs or different analysis methods can be allocated to different ROI types within one image.

Screening with oncology markers

Tissue evaluation with cancer specific markers, for example Ki67, p21, p53, Stathmin, bTubulin, etc.

TMA Screening & Analysis

Analysis Software for Tissue MicroArrays (TMA) with variable number of cores. Semi automatic naming of TMA cores. Export of TMA core results together with cores names into excel files.



Kidney glomeruli detection & fibrosis evaluation

Software for automatic detection of kidney glomeruli and evaluation of fibrotic structures within glomeruli. Analysis of interstitial fibrosis.

congress

Events

You will find us:

cyberLAGO

20. Januar 2019
Inside Data Bodensee – cyberLAGO e.V.
Workshop zur Anwendung von Deep Learning in Bildanalyse
cyberLAGO e.V. – Blarerstraße 56, 78462 Konstanz

Weitere Informationen

DBT

9. April 2019, 10-17 Uhr
Deutschen Biotechnologietage (DBT) Symposium
Vortrag zum Thema Bio-Daten und Deep Learning
In Würzburg

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Etengo-Symposium

16. Mai 2019
Etengo-Symposium 2019
Workshop zur Anwendung von Deep Learning in Bildanalyse
WIRSOL Rhein-Neckar-Arena in Hoffenheim

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Scion Konstanz

19. und 20. Juli 2019
Scion Konstanz
iniziert durch BioLago
und HS Analysis GmbH
In Konstanz

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Scion Logo

25.-27. Oktober 2019
Scion : Vertrauen in KI
Technologiefabrik – Haid-und-Neu-Straße 7, Karlsruhe

Weitere Informationen

Past Events

Scion

26. – 28. Oktober 2018
2: Scion : Vertrauen in KI
Technologiefabrik – Haid-und-Neu-Straße 7, Karlsruhe

Weitere Informationen

House of Pharma

11. September 2018
Auf der Spitze des Hype Cycles: Wie Deep Learning die Entwicklung neuer Wirkstoffe und Therapien mit signifikanter Zeit- und Kostenersparnis ermöglichen wird.
Frankfurt am Main

Weitere Informationen

IHK

5. Juli 2018, 14-18.00 Uhr
Erster Tag der Künstlichen Intelligenz
IHK Karlsruhe

Weitere Informationen

Scion

23 + 24 Juni 2018
1: Scion : Vertrauen in KI
Technologiefabrik – Haid-und-Neu-Straße 7, Karlsruhe

Weitere Informationen

Steinbeis

Freitag, 15. Juni 2018
Maschinelles Lernen: Produktionsanwendungen in der Robotik
ZKM – Zentrum für Kunst und Medien, Karlsruhe

Weitere Informationen

CEBIT

14. Juni 2018
CEBIT
Hannover

Weitere Informationen

Michelin

12. Juni 2018 16-20:00 Uhr
Qualitätssicherung mit VR und KI
Michelin Reifenwerke Karlsruhe

Weitere Informationen

Our blog (german):

Rückblick: Scion Herbst 2018 “Vertrauen in KI”

Nach all dem Tagesgeschäft, das uns in der Folge unserer Jahreskonferenz Scion schnell wieder ereilte, nehmen wir einen Rückblick auf Scion Herbst 2018 vor. Ein ganz großer Dank geht an unsere Partner und insbesondere an die Speaker, Teilnehmerinnen und Teilnehmer, ohne die Scion 2018 in dieser Größenordnung und mit einem solch positiven Widerhall überhaupt nicht […]

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Pathologie, Mikroskopie und automatisierte Bildanalyse

Privatdozentin Dr. Afsaneh Soruri hat an der Universität Göttingen Immunologie, Biochemie und Mikrobiologie studiert. Promoviert wurde sie auf dem Gebiet der Antigenpräsentation durch Dendritische Zellen. In Ihrer Habilitation beschäftigte sie sich mit dem Thema Migration und Reifung von Antigen-Präsentierenden-Zellen in vivo. Das besondere Interesse der Naturwissenschaftlerin gilt der Bedeutung der Antigenpräsentation im Tumorgewebe. In 2009 […]

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Scion Herbst 2018: Medikamentenforschung von Bayer und Pathologie aus Mannheim

Die Bayer AG wurde 1863 in Barmen, das heute zu Wuppertal gehört, von Friedrich Bayer (1825-1880) gegründet. Der Hauptsitz befindet sich gegenwärtig in Leverkusen. 2017 hatte Bayer einen Jahresumsatz von 35 Milliarden Euro. Das weltweit tätige Unternehmen mit knapp 100.000 Mitarbeitern ist in der chemischen und pharmazeutischen Industrie angesiedelt. Dr. Christoph Schatz hat in Berlin, […]

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Zeiss and HS Analysis cooperate in terms of Microscopy and Digital Image Analysis

Englisch Version (for German Version see below) Scion Herbst 2018 Forum & Hackathon (26.-28.10.18) is only a few days ahead. Beforehand we will talk about speakers who are going to contribute their expertise to the annual life science conference in Karlsruhe. The worldwide company Zeiss has a long history and tradition. Named after its founder Carl Zeiss […]

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services

Services

HS Analysis works closely with you to develop target-oriented software solutions.

You get modular and scalable solutions for efficient analysis of histological studies.

This reduces time and cost and increases return on equity.

Get the right solutions for your requirements and be beyond the market leaders in your area.

HS Analysis is a company that is established in the pharmaceutical industry with proven software solutions.

get-connected

TEAM

Sergey Biniaminov

Dipl.rer.pol.techn.

CEO / Founder


Software development:

Andreas Schaarschmidt

Viktor Eberhardt

Philipp Marquardt

Timo Koch

Sascha Seifert

Sebastian Dahnert

Michael Roth

Hendrik Whelan

Michail Rybakov

Vitaly Biniyaminov



Strategic consulting:

Cedric Larrat



Operational management:

Leistungen: Andreas Sütterlin

The team got together at KIT (Karlsruhe Institute of Technology) and pursue the aim, to build machine vision tools for practicioners in the health sector.

HS Analysis employs computer scientists who use modern approaches in the field of artificial intelligence and create software for automated quantification fo tissue samples. HS Analysis also works with designers creates new models, rethink existing processes in life science sector and provide new proposals for software solutions adapted to the corporate identity. This combination of experts in Design Thinking, Data Science and Deep Learning approaches is unique and advance research groups in their everyday work.

 

Drop us a line!