Software for Digital Histology

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HS Analysis provides tissue analysis software for digital pathology and microscopy images.
Get best practice analysis solutions derived with state of the art artificial neural networks / Deep Learning to automate quantification of your images.

technology

Technology

The most up-to-date artificial intelligence is one key technology of automatic interpretation of tissue samples in the software of HS Analysis. Technically speaking, virtual slides are analyzed with deep learning. Virtual slides are digital images, that are produced by microscope roboters called slide scanner. In this way you quickly get quantitative results about effects of drug candidates on tissue.

Specialists of HS Analysis use the appropriate technology depending on requirements of customers.
Two examples of most used technologies are listed below.

Digital pathology is a promising method for quantitative automatization in pharmaceutical research. The key technology was the introduction of Whole-Slide Imaging (WSI) with digital slide scanners. They allow virtualization of the whole slide with large tissue sections in high microscopic resolution. Combination of WSI with automatic detection and quantification software enables numerous new possibilities and methods to search for drugs against diseases. HS Analysis develops automatic WSI quantification solutions for efficient workflows in pharmaceutical research. Our solutions are compatible with all slide scanner file formats.
Recent evolution in artificial neural networks allows reliable recognition of structures with complex morphology traits, similar like the human brain does. HS Analysis specialized in neural network applications and Deep Learning to detect your Region of Interest in automatic manner. Avoid manual annotations for ROI definition to achieve high throughput with short analysis times.
scope

Scope

Our quality standards apply also in terms of service, technical expertise and advice.
Our dedicated employees are happy to assist you with know-how and experience in your daily business.

  • 3D reconstruction & analysis of serial slides.

    Anatomy

    3D reconstruction & analysis of serial slides.
  • Detection of frequency and distribution of IHC labeled blood vessels (e.g. as indicator of tumor malignancy).

    Angiology

    Detection of frequency and distribution of IHC labeled blood vessels (e.g. as indicator of tumor malignancy).
  • Analysis of gut wall and gut villi & crypt.

    Gastroenterology

    Analysis of gut wall and gut villi & crypt.
  • Glomeruli detection & analysis of interstitial fibrosis in Kidney.

    Nephrology

    Glomeruli detection & analysis of interstitial fibrosis in Kidney.
  • Quantification of labeled parameters in skin.

    Dermatology

    Quantification of labeled parameters in skin.
  • 3D Analysis of Brain structures and Plaque Analysis in Alzheimer´s disease.

    Neuroscience

    3D Analysis of Brain structures and Plaque Analysis in Alzheimer´s disease.
  • Quantification of proliferation markers like Ki-67, p53, p21, Stathmin, H-Scoring etc.

    Oncology

    Quantification of proliferation markers like Ki-67, p53, p21, Stathmin, H-Scoring etc.
  • Alveoli analysis in lung tissue.

    Pneumology

    Alveoli analysis in lung tissue.
  • Osteon quantification, Osteocytes, Volkman’s Canal, Haversian Canal

    Osteology

    Osteon quantification, Osteocytes, Volkman’s Canal, Haversian Canal
  • 3D reconstruction & analysis of serial slides.

    Anatomy

    3D reconstruction & analysis of serial slides.
  • Detection of frequency and distribution of IHC labeled blood vessels (e.g. as indicator of tumor malignancy).

    Angiology

    Detection of frequency and distribution of IHC labeled blood vessels (e.g. as indicator of tumor malignancy).
  • Analysis of gut wall and gut villi & crypt.

    Gastroenterology

    Analysis of gut wall and gut villi & crypt.
  • Glomeruli detection & analysis of interstitial fibrosis in Kidney.

    Nephrology

    Glomeruli detection & analysis of interstitial fibrosis in Kidney.
  • Quantification of labeled parameters in skin.

    Dermatology

    Quantification of labeled parameters in skin.
  • 3D Analysis of Brain structures and Plaque Analysis in Alzheimer´s disease.

    Neuroscience

    3D Analysis of Brain structures and Plaque Analysis in Alzheimer´s disease.
  • Quantification of proliferation markers like Ki-67, p53, p21, Stathmin, H-Scoring etc.

    Oncology

    Quantification of proliferation markers like Ki-67, p53, p21, Stathmin, H-Scoring etc.
  • Alveoli analysis in lung tissue.

    Pneumology

    Alveoli analysis in lung tissue.
  • Osteon quantification, Osteocytes, Volkman’s Canal, Haversian Canal

    Osteology

    Osteon quantification, Osteocytes, Volkman’s Canal, Haversian Canal
projects-two

Projects

Research experts in pharmacology, bioscience and in university medical centers are permanently expected to increase efficiency and reduce timeinvest and cost.

HS Analysis delivers software solutions for precise image analysis. In that way the researcher is going to be supported to get qualitative and reproducible data.

The system reduces human errors, which are possible in manual evaluation. It finally allows to get Big Data results in a short time and at the end to analyse, manage and present them. That allows researchers to fulfill continuously increasing expectations concerning efficiency and output of results.

details

Glomeruli Detection

Detection of glomeruli by using a tensorflow model for brightfield data.
 

Cell Counting

Segmentation and counting of cells.
 

Internalization

Analysis of insulin receptors inside and outside of cytoplasm and the change over time.
You can run this workflow at the digital microscopy platform APEER.

Scratch Assay

Analysis of samples with scratches and the change of cell area over time.
 
You can run this workflow at the digital microscopy platform APEER.

Real time detection on microscopy devices

You look through the microscope and see in real time markings of the objects relevant to you. Subsequently, an automatic quantification of the detected objects takes place.

Blood vessel analysis

Blood vessels can be marked with immunohistochemistry.
This allows blood vessel counting and analysis of blood vessel distribution.
 

 

Annotation Software to set region of interests (ROI)

Manual drawing of regions of interest (ROI) as well as automatic ROI detection. Image analysis can be restricted to ROIs or different analysis methods can be allocated to different ROI types within one image.

Screening with oncology markers

Tissue evaluation with cancer specific markers, for example Ki67, p21, p53, Stathmin, bTubulin, etc.

TMA Screening & Analysis

Analysis Software for Tissue MicroArrays (TMA) with variable number of cores. Semi automatic naming of TMA cores. Export of TMA core results together with cores names into excel files.



Kidney glomeruli detection & fibrosis evaluation

Software for automatic detection of kidney glomeruli and evaluation of fibrotic structures within glomeruli. Analysis of interstitial fibrosis.

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Events

 

You will find us here:

Zukunftstüftler Logo
September 18, 2019
127/5000 Future inventors - the conference for the minds of digital transformation
in the Technikfabrik Karlsruhe

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September 26, 2019
Creating confidence in the AI and securing profitability for SMEs.
Business Forum Ettlingen

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Nachfolgeforum Logo
October 15, 2019
At the Successor Forum 2019 we talk about Artificial Intelligence and implications for successor design.
Europa Park, Rust

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BioRN Logo
November 11, 2019
The BioRN Annual Conference "Artificial Intelligence meets Health" will take place on 11.11.2019 in the DKFZ.

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HS Pforzheim Logo
November 14, 2019
You are the future of tomorrow!
On the way to practical experience with Deep Learning in Life Science.
University of Applied Sciences Pforzheim,
Medical Imaging

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Scion Logo
23-25th October 2020
Scion : Vertrauen in KI
Technologiefabrik – Haid-und-Neu-Straße 7, Karlsruhe

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Past events

BioLAGO Logo
July 7, 2019
Seven creative designers from Karlsruhe have seven minutes to present themselves and their company.

Event on Facebook
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BioLAGO Logo
June 27, 2019
BioLAGO „Drugs, Diagnostics, Devices & Data – Matchmaking with Ireland”
Vortragsthema: „Künstliche Intelligenz: Deep Learning in der Medizin, Mythos oder Realität?“

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20 May 2019
2nd European Pathology Congress in Berlin
Vortrag zum Thema Opportunities and risks of AI integration in daily routine in pathology today

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Etengo-Symposium
16 May 2020
Etengo-Symposium 2019
Workshop zur Anwendung von Deep Learning in Bildanalyse
WIRSOL Rhein-Neckar-Arena in Hoffenheim

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DBT
April 9, 2019, 10-17 clock
Deutschen Biotechnologietage (DBT) Symposium
Vortrag zum Thema Bio-Daten und Deep Learning
In Würzburg

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all past events

Scion
October 26-28, 2018
2: Scion : Vertrauen in KI
Technologiefabrik – Haid-und-Neu-Straße 7, Karlsruhe

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House of Pharma
September 11, 2018
Auf der Spitze des Hype Cycles: Wie Deep Learning die Entwicklung neuer Wirkstoffe und Therapien mit signifikanter Zeit- und Kostenersparnis ermöglichen wird.
Frankfurt am Main

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IHK
5 July 2018, 2-6 pm
Erster Tag der Künstlichen Intelligenz
IHK Karlsruhe

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Scion
23 + 24 June 2018
1: Scion : Vertrauen in KI
Technologiefabrik – Haid-und-Neu-Straße 7, Karlsruhe

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Steinbeis
Friday, June 15, 2018
Maschinelles Lernen: Produktionsanwendungen in der Robotik
ZKM – Zentrum für Kunst und Medien, Karlsruhe

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CEBIT
June 14, 2018
CEBIT
Hannover

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Michelin
June 12, 2018 16:00 - 20:00
Qualitätssicherung mit VR und KI
Michelin Reifenwerke Karlsruhe

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Our Blog:

services

Services

HS Analysis works closely with you to develop target-oriented software solutions.

You get modular and scalable solutions for efficient analysis of histological studies.

This reduces time and cost and increases return on equity.

Get the right solutions for your requirements and be beyond the market leaders in your area.

HS Analysis is a company that is established in the pharmaceutical industry with proven software solutions.

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TEAM

Sergey Biniaminov

Dipl.rer.pol.techn.

CEO / Founder


Data Science + Software development:

Andreas Schaarschmidt

Viktor Eberhardt

Philipp Marquardt

Timo Koch

Lukas Bueß

Martin Dembinsky

Sebastian Murgul

Michael Roth

Vitaly Biniyaminov





Operational management:

Leistungen: Andreas Sütterlin

The team got together at KIT (Karlsruhe Institute of Technology) and pursue the aim, to build machine vision tools for practicioners in the health sector.

HS Analysis employs computer scientists who use modern approaches in the field of artificial intelligence and create software for automated quantification fo tissue samples. HS Analysis also works with designers creates new models, rethink existing processes in life science sector and provide new proposals for software solutions adapted to the corporate identity. This combination of experts in Design Thinking, Data Science and Deep Learning approaches is unique and advance research groups in their everyday work.

 

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